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Alternative toxicological methods
edited by Harry Salem, Sidney A. Katz.
D.H. Hill Library Call Number
  Stacks (8th floor) RA1199.4 .A46 A45 2003 (Browse Shelf) Available
Other Authors
  • ISBN: 084931528X (alk. paper)
  • ISBN: 0203008790 (eBook)
  • OCLC Number: 51098222
  • Includes bibliographical references and index.
Table of Contents

Ch. 10. Evaluation and Refinement of the Bovine Cornea Opacity and Permeability Assay / John L. Ubels, James D. Paauw and Phillip L. Casterton -- Ch. 11. Corneal Organ Culture for Ocular Toxicity Test of Commercial Hair Care Products / Fu-Shin X. Yu and Ke-Ping Xu -- Ch. 12. Human Corneal Equivalents for In Vitro Testing / May Griffith and Erik Suuronen -- Ch. 13. The EpiOcular Prediction Model: A Reproducible In Vitro Means of Assessing Ocular Irritancy / Mitchell Klausner, Patrick J. Hayden, Bridget A. Breyfogle, Kristen L. Bellavance, Melissa M. Osborn, Daniel R. Cerven, George L. DeGeorge and Joseph Kubilus --Ch. 14. Three-Dimensional Construct of the Human Corneal Epithelium for In Vitro Toxicology / D. H. Nguyen, Roger W. Beuerman, Bart DeWever and Martin Rosdy -- Ch. 15. The Human Corneal Epithelial HCE-T TEP Assay for Eye Irritation: Scientific Relevance and Summary of Prevalidation Study Results / Sherry L. Ward, Maximo Gacula, Jr. and Henry F. Edelhauser -- Pt. III. Dermal Testing Alternatives / Harry Salem and Sidney A. Katz -- Ch. 16. Alternative Methods for Dermal Toxicity Testing / Robert L. Bronaugh -- Ch. 17. Allergic Contact Hypersensitivity: Mechanisms and Methods / Denise M. Sailstad --Ch. 18. Validating In Vitro Dermal Absorption Studies: An Introductory Case Study / Robert P. Zendzian and Michael Dellarco -- Ch. 19. A Molecular Diagnostic Approach to Irritant or Allergic Patch Testing Using the DermPatch / Melissa M. Fitzgerald, Vera B. Morhenn, Stacey B. Humphrey, Nirmala Jayakumar and Lawrence A. Rheins -- Ch. 20. In Vitro Skin Equivalent Models for Toxicity Testing / Patrick J. Hayden, Seyoum Ayehunie, G. Robert Jackson, Sarah Kupfer-Lamore, Thomas J. Last, Mitchell Klausner and Joseph Kubilus -- Pt. IV. A Case Study in the Use of Alternatives to Determine the Mechanism of Sulfur Mustard Action / William J. Smith --Ch. 21. Cellular Resistance of Tetrahymena to Sulfur Mustard / Peter L. Platteborze, James E. Sistrunk and William J. Smith -- Ch. 22. Studies of Cellular Biochemical Changes Induced in Human Cells by Sulfur Mustard / William J. Smith, Offie E. Clark III, Fred M. Cowan, Maura E. DeJoseph, Charisse Davenport and Clark L. Gross -- Ch. 23. Human Keratinocyte Inflammatory Transcript Gene Activity Following Sulfur Mustard / John J. Schlager, Kashif Ali, Hilma R. Benjamin, Claire F. Levine, Douglas P. Avery and James H. Clark --Ch. 24. Evaluation of Cytotoxicity Assays of Human Epidermal Keratinocytes Exposed In Vitro to Sulfur Mustard / Susan A. Kelly, Juanita J. Guzman, Clark L. Gross and William J. Smith -- Ch. 25. Comparison of Spectrophotometric and Fluorometric Assays of Proteolysis in Cultured Human Cells Exposed to Sulfur Mustard / Susan A. Kelly, Charlene M. Corun, Marian R. Nelson, Clark L. Gross and William J. Smith -- Ch. 26. Effects of Low Dose Sulfur Mustard on Growth and DNA Damage in Human Cells in Culture / William J. Smith, Bethany S. Toliver, Offie E. Clark III, Janet Moser, Eric W. Nealley, Juanita J. Guzman and Clark L. Gross --Ch. 27. Imaging Sulfur Mustard Lesions in Basal Cells and Human Epidermal Tissues by Confocal and Multiphoton Laser Scanning Microscopy / Robert J. Werrlein and Janna S. Madren-Whalley -- Ch. 28. Suppression of Sulfur Mustard-Increased IL-8 in Human Keratinocyte Cell Cultures by Serine Protease Inhibitors: Implications for Toxicity and Medical Countermeasures / Fred M. Cowan, Clarence A. Broomfield and William J. Smith -- Ch. 29. Development of Medical Countermeasures to Sulfur Mustard Vesication / William J. Smith, Michael C. Babin, Robyn C. Kiser and Robert P. Casillas --Ch. 33. Two-Photon Fluorescence Microscopy: A Review of Recent Advances in Deep-Tissue Imaging / Chen-Yuan Dong, Lily Hsu, Ki-Hean Kim, Christof Buehler, Peter D. Kaplan, Thomas D. Hancewicz and Peter T. C. So -- Pt. VI. Role of Transgenics and Toxicogenomics in the Development of Alternative Toxicity Tests / Jerry Heindel -- Ch. 34. The Application of Genomics and Proteomics to Toxicological Sciences / Stephan Chevalier, William D. Pennie and Ian Kimber -- Ch. 35. Use of Transgenic Animals in Regulatory Carcinogenicity Evaluations / Frank D. Sistare and Abigail C. Jacobs --Ch. 36. Changes in Gene Expression after Exposure to Organophosphorus (OP) Agents / Jennifer W. Sekowski, Kevin P. O'Connell, Akbar S. Khan, James J. Valdes, Maryanne Vahey, Martin Nau, Maha Khalil and Mohyee E. Eldefrawi -- Pt. VII. Recent Innovations in Alternatives / Harry Salem and Sidney A. Katz -- Ch. 37. Archival Data in Toxicology: Minimizing Need for Animal Experiments / Millard M. Mershon -- Ch. 38. Information Management at the Library of Congress: An Overview with Special Reference to Biomedicine / Roman B. Worobec --Ch. 39. World Wide Web Biomedical, Chemical, and Toxicological Information Resources from the National Library of Medicine / George C. Fonger, James Knoben, Stephanie Publicker, Philip Wexler and Georgette Whiting -- Ch. 40. In Silico Approaches for Physiologically Based Pharmacokinetic Modeling / Martin Beliveau and Kannan Krishnan -- Ch. 41. In Silico Application of Quantum Chemical Methods for Relating Toxicity to Chemical Reactivity / William White -- Ch. 42. In Silico Cardiac Toxicity: Increasing the Discovery of Therapeutics through High-Performance Computing / Csaba K. Zoltani and Steven I. Baskin --Ch. 4. Validation and Regulatory Acceptance of Alternative Test Methods: Current Situation in the European Union / Julia H. Fentem and Michael Balls -- Ch. 5. Integrated In Vitro Approaches for Assessing Systemic Toxicity / Anna Forsby and Bas Blaauboer -- Ch. 6. Summary of the OECD's New Guidance Document on the Recognition, Assessment, and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation / Errol Zeiger --Ch. 43. Submillimeter-Wave Frequency Studies of the Vibrational Modes of Deoxyribonucleic Acid: A Metric for Mutagenicity? / T. R. Globus, B. L. Gelmont, M. Bykhovskaia, J. Hesler, D. L. Woolard, A. C. Samuels, J. O. Jensen, H. Salem and W. R. Loerop -- Ch. 44. Trophoblast Toxicity Assay (TTA): A Gestational Toxicity Test Using Human Placental Trophoblasts / Harvey J. Kliman.Ch. 7. Pain and Distress Management in Animal Research and Testing: The Humane Society of the United States Pain and Distress Initiative / Martin L. Stephens, Francine Dolins, Lori Donley, Adrienne M. Navarro, Kathleen M. Conlee and Andrew N. Rowan -- Pt. II. Development of Predictive Methods Based on Mechanisms of Eye Irritation at the Ocular Surface: Meeting Industry and Regulatory Needs / Sherry L. Ward and Wiley A. Chambers -- Ch. 8. Meeting Industry and Regulatory Needs for Alternative Test Methods to the Draize Rabbit Eye Irritation Test / Sherry L. Ward -- Ch. 9. The Ocular Surface: Barrier Function and Mechanisms of Injury and Repair / Martin Reim --Pt. I. Progress in the Validation and Regulatory Acceptance of Alternatives / Neil L. Wilcox -- Ch. 1. Historical Developments in the Humane Care and Use of Research Animals: The First 4000 Years / Harry Salem and Sidney A. Katz -- Ch. 2. A History of Interagency Approaches to Alternatives and Establishment of the Interagency Regulatory Alternatives Group / Sidney Green -- Ch. 3. The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Recent Progress in the Evaluation of Alternative Toxicity Testing Methods / William S. Stokes --Pt. V. Neurotoxicology: Molecular Biomarkers, Transgenics, and Imaging Technologies / William J. Slikker, Jr. and Thomas J. Sobotka -- Ch. 30. Molecular Neurotoxicology of 6-Hydroxydopamine and Methamphetamine: Lessons Derived from Transgenic Models / Jean Lud Cadet -- Ch. 31. A Microassay Method Using a Neuroblastoma Cell Line to Examine Neurotoxicity of Organophosphate Mixtures / Laurie E. Roszell, Benjamin C. Kramer and Glen J. Leach -- Ch. 32. Development of Integrin Expression as a Molecular Biomarker for Early, Sensitive Detection of Neurotoxicity / Joyce E. Royland --